Hormonal imbalance: why we often overestimate it and what is really worth addressing

Reviewed by Markéta Camfrlová, MSc.
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Hormonal imbalance: why we often overestimate it and what is really worth addressing
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  • “Hormonal imbalance” is not a single diagnosis. Hormones are naturally dynamic and, apart from specific disorders (thyroid, PCOS, hyperprolactinemia, perimenopause…), the term is often used vaguely as a universal explanation for everything.

  • For nonspecific issues, first look for the primary cause and rule out diagnoses; only then does “optimisation” make sense — pillars such as adequate energy (especially in active women), sleep, quality diet, appropriate physical activity and stress management.

What are hormones, and what does their “imbalance” mean?

In medicine, hormones are described as chemical “messengers” that coordinate metabolism, growth, reproduction, mood and sleep via receptors — in short, everything in the body. The endocrine system (e.g., pituitary gland, thyroid, pancreas, ovaries) is regulated by feedback to maintain internal stability (homeostasis).

This leads to the idea that there is some ideal state of “perfect balance.” But in reality, the levels of many hormones are naturally dynamic (sensitive to cycle, stress, sleep, energy intake, illness).

Homeostasis is often simplified to “hormonal balance.” The problem is that outside of specific diagnoses, “imbalance” is used very vaguely, without clear criteria for how to measure it or when it is “fixed.” People (such as authors of popular science books on hormonal balance), who label “hormonal imbalance” as the cause of most problems, do not specify how to recognise that balance has been achieved, except by describing an ideal appearance and experience.

Why “hormonal imbalance” is mainly marketed to women

A scholarly article analysing "self‑help” books on hormonal balance shows that in the vast majority of cases, they are written primarily for women and focus on the female body. Below, we’ll discuss what scientists found in their analysis of these books.

Endocrine determinism: “hormones are to blame for everything”

In many popular frameworks, health and well‑being are reduced to the endocrine system — “optimise your hormones and you’ll solve everything.” Book authors then attribute “dysregulation” to a very wide range of issues: mood swings, weight changes, fatigue, “brain fog,” insomnia, skin and hair changes, infertility or sexual dysfunction.

The ideal of the “properly” hormonally balanced woman

The “hormonally balanced” woman in these books is portrayed as slim, attractive, calm, energetic and sexually desirable.

This is illustrated extremely vividly in a passage about the “ideal hormonal specimen,” where balance is recognised by shiny hair, clear skin, stable mood, absence of cravings and flawless work performance.

At the same time, “deviations” (crying under stress, sweating, loss of interest in “looking good,” less people‑pleasing in menopause) are framed as signs of hormonal failure — not as a complex biopsychosocial reality, but as “lack of control over hormones.”

Life stages in which women are most often attributed “imbalance”

Books typically emphasise puberty, the postpartum period and middle age/perimenopause as phases when a woman is “at risk” of imbalance in multiple hormones (estrogen, progesterone, thyroid hormones, insulin, etc.).

Hormonal imbalance: why we often overestimate it and what is really worth addressing
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When it’s a real endocrine disorder (and when it’s natural fluctuations)

From a clinical perspective, it’s not useful to think of “hormonal imbalance” as a single diagnosis. It’s more useful to distinguish:

Physiological/natural changes (not a “disorder”)

  • Changes during the menstrual cycle

  • Puberty, pregnancy, breastfeeding

  • Perimenopause and menopause (hormonal fluctuations and subsequent decline in ovarian production).

In menopause, it’s a real biological change. In (peri)menopause, ovarian function and sex hormone levels change, and hot flashes, sleep disturbances, mood changes, urogenital issues, etc., may occur.

Specific endocrine/gynaecological disorders

Typical examples:

Thyroid dysfunction (hypo/hyperthyroidism): may manifest as fatigue, weight changes, palpitations, psychological changes and also menstrual irregularity or infertility.

It is often associated with weight gain, but here it’s important to set expectations. In untreated hypothyroidism, weight gain is typically mild, often about 2–5kg (approx. 5–10 lbs), and a significant part may be retained water and salt, not necessarily fat.

This means that if someone gains 15–20kg, it is very unlikely that the thyroid alone would explain it (though it may be one piece of the puzzle).

PCOS (polycystic ovary syndrome): a common endocrine cause of irregular menstruation and hyperandrogenism.

Hyperprolactinemia, disorders of the hypothalamic–pituitary–ovarian axis, premature ovarian failure, etc. (selection always based on symptoms and findings).

When to pay attention and what makes sense to investigate

  • Newly developed or significantly worsened menstrual irregularity

  • Amenorrhea, bleeding outside the cycle, very heavy bleeding

  • Infertility

  • Galactorrhea (spontaneous milk discharge)

  • New significant signs of hyperandrogenism,

  • Systemic symptoms (severe fatigue, palpitations, tremor, unexplained weight loss, etc.).

Why weight gain and fatigue are often not “hormones”

Weight gain and fatigue are often the most common “evidence” of a supposed hormonal imbalance.

But both symptoms have a huge number of common causes, for example:

  • Chronically shortened sleep and poor sleep quality (and with it, increased appetite, worse stress regulation, less spontaneous movement)

  • Chronic stress, overload, burnout

  • Low protein and fibre intake, irregular meals → evening cravings

  • Sedentary lifestyle, low NEAT (spontaneous daily activity)

  • Alcohol

  • Certain medications (some antidepressants, corticosteroids, some antipsychotics, etc.)

  • Anaemia/low iron, vitamin D deficiency (in some people), chronic inflammation, sleep apnea…

The point is not that hormones play no role… but that it’s not reasonable to automatically blame them as the main culprit when there is often a simpler explanation.

How to improve hormonal health

Hormonal health is highly complex — it’s not governed by a single “switch,” but by a network of interconnected axes (e.g., hypothalamic–pituitary–ovarian axis, thyroid, adrenal glands and metabolic hormones). This means that what helps one woman may not work for another. Intervention always needs to be tailored to which issues are dominant and which hormones or regulatory systems are likely involved.

Still, it’s possible to generally identify several “basic pillars” that tend to benefit most scenarios — typically quality sleep, sufficient and regular/adequate energy and nutrient intake, appropriate physical activity and stress management. However, if you’re dealing with nonspecific issues (fatigue, mood swings, weight changes, irregular cycle, etc.), the most important step is often elsewhere. First, look for the primary cause and rule out specific diagnoses (e.g., thyroid disorders, PCOS, hyperprolactinemia or perimenopause) — only then does “lifestyle optimisation” have a clear direction and a realistically measurable effect.

Hormonal imbalance: why we often overestimate it and what is really worth addressing
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1. Energy availability: most often a problem in highly active women and athletes

Relative Energy Deficiency Syndrome (often referred to as RED‑S — Relative Energy Deficiency in Sport) is a condition where the body has chronically too low energy availability — meaning that after subtracting energy expended in training, there isn’t enough energy from food left for normal physiological functions.

The body then adaptively switches to “energy‑saving mode” and starts limiting processes that are not essential for immediate survival. This can typically lead to:

  • Menstrual cycle/ovulation disorders (in women)

  • Poorer recovery, more frequent illness and decreased performance

  • Negative impact on bones (higher risk of stress fractures)

  • Changes in mood, sleep and sometimes even metabolism.

2. Body weight and visceral fat

On the other hand, the opposite extreme is not good either. Chronically high caloric intake leads to excessive accumulation of adipose tissue, which is hormonally active.

Adipose tissue is not just “storage” — it produces signalling molecules (adipokines such as leptin or adiponectin) and affects metabolism and other hormonal axes.

If obesity is present, data show that weight reduction (by various safe means) can improve the profile of sex hormones and related health outcomes.

For optimal hormonal health, it’s ideal to maintain a healthy body fat percentage.

Learn more: 10 Tips on How to Start Eating Healthy

3. Sleep and circadian rhythm

Sleep is not just passive rest. It is an active regulatory state during which circadian clocks are synchronised and controlled changes occur in the autonomic nervous system and endocrine hormone secretion. During sleep, the hypothalamus helps set the daily rhythm of many hormones — typically cortisol, which physiologically peaks around waking and drops toward evening. With sleep deprivation, this rhythm can shift, and cortisol may remain elevated even in the evening, which then worsens falling asleep and supports the “vicious cycle” of stress activation.

Lack of sleep is associated with a number of problems

Chronic sleep deprivation is associated with impaired glucose regulation and lower insulin sensitivity, changes in hunger and satiety hormones (more frequent increased appetite and overeating), poorer immune function and higher inflammatory activation. It also increases the risk of mood disorders, worsens attention and performance and in long‑term population data is linked to higher cardiovascular risk.

You won’t improve your sleep overnight

The basics are regularity (same wake‑up and bedtime), aim for ≥7 hours of sleep and expose yourself to daylight in the morning to properly set your circadian rhythm. It also helps to limit caffeine in the afternoon/evening, avoid alcohol and large meals right before bed and make your bedroom a “sleep zone” (dark, quiet, cool, minimal distractions). If insomnia lasts for months, the best‑supported approach is CBT‑I (cognitive‑behavioural therapy for insomnia).

Among food supplements, melatonin may have a beneficial effect on sleep quality (especially when the circadian rhythm has shifted).

4. Diet: quality and consistency rather than “special” diets

You don’t have to jump straight into gluten‑free regimens or other unnecessarily restrictive diets. In most cases, it’s much more important to have a quality, balanced diet and adequate caloric intake. This will help you better manage hunger and cravings, reduce fatigue, support focus, stabilise glycemia, and at the same time, make it easier to lose weight or maintain a healthy amount of body fat.

Basic guidelines

  • Enough protein (satiety, muscles, recovery)

  • Enough fibre (glycemia, microbiome, satiety)

  • Predominance of minimally processed foods (better energy intake control, more micronutrients)

  • Regular intake of fruits/vegetables, legumes, whole grains, quality fats

5. Stress and mental health

Cortisol is an adaptive hormone — the problem is chronic stress load combined with low energy and poor sleep. This can affect the cycle, appetite, compensatory “overeating” and perception of symptoms.

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6. Endocrine disruptors: reduce exposure where it’s easy

Some chemicals can mimic or disrupt hormonal signalling (endocrine disruptors). From a practical standpoint, it makes sense to focus on sources you can reasonably influence (e.g., some plastics, cosmetics, food packaging).

Simple steps with a good “effort/effect” ratio:

  • Don’t heat food in plastic (use glass/ceramic instead)

  • Limit heavily perfumed products, choose “fragrance‑free” where possible

  • Ventilate, dust (some exposure comes from dust)

  • Wash hands before eating (simple but effective)

7. Alcohol and smoking

Alcohol can interfere with multiple hormonal systems (e.g., stress hormones, sex hormones) and long‑term brings a number of health risks. The only safe alcohol intake is zero.

Smoking is associated with changes in reproductive hormones. In women, among other things, an anti‑estrogenic effect and a shift in the ratio of androgens to estrogens are described.

Food supplements for hormonal health

With food supplements, a simple rule applies: they make sense when they target a specific cause or deficiency. Therefore, it is not possible to recommend food supplements in general for “hormonal imbalance.”

For example, during menopause, it may make sense to supplement vitamin D and calcium, especially if their intake from the diet is chronically low — primarily to support bone health. Creatine also appears interesting, as some studies show positive results for muscle function and selected indicators related to bone quality.

In PCOS, inositol is sometimes considered — in some women, it can help improve certain biochemical and metabolic markers, especially in the area of glucose regulation and insulin sensitivity.

If the diet is lacking in micronutrients, a multivitamin may help. However, the primary approach should be to address the deficiency by changing the diet.

Bottom line

“Hormonal imbalance” is often a vague label for nonspecific issues. That’s why it makes sense to first look for the primary cause (sleep, stress, energy availability, anaemia, thyroid, PCOS, perimenopause). Only then does “optimisation” have a clear direction. Most women will benefit from sticking to the basics — enough energy (especially in active and slim women in deficit), quality sleep, a balanced diet and appropriate physical activity — instead of restrictive diets, detoxes and random supplements.

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